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Cannabis contains at least 400 different chemicals. Its main mind-altering ingredient is THC (delta-9-tetrahydrocannabinol). The amount of THC in marijuana determines the drug’s strength. THC levels are affected by many factors, including plant type, weather, soil, and time of harvest.

THC, or tetrahydrocannabinol, is the chemical responsible for most of marijuana's psychological effects. It acts much like the cannabinoid chemicals made naturally by the body.

THC stimulates cells in the brain to release dopamine, creating euphoria, according to NIDA. It also interferes with how information is processed in the hippocampus, which is part of the brain responsible for forming new memories.

Researchers have found that THC, the active chemical in marijuana, slows the formation of amyloid plaques by blocking the enzyme in the brain that makes them. These plaques are what kill brain cells and cause Alzheimer's.

The higher % THC, and lower % CBD causes a more clear headed energetic marijuana effect.
The lower % THC, and higher % CBD  causes a sluggish, drowsy, more ‘stoney’ feeling of high.
High % THC, and high % CBD produces a strong head and body high said to feel dreamlike.